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How Myeloma Plays Hide and Seek With CAR T Cells

Source link : https://newshealth.biz/health-news/how-myeloma-plays-hide-and-seek-with-car-t-cells/

TOPLINE: G protein-coupled receptor, class C, group 5, member D (GPRC5D) loss after chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM) occurs through biallelic genetic inactivation and hypermethylation-driven epigenetic silencing. Among 10 patients who relapsed, eight showed GPRC5D loss, while two had mixed expression. METHODOLOGY: Researchers conducted whole-genome sequencing (WGS) and whole-genome bisulfite […]

The post How Myeloma Plays Hide and Seek With CAR T Cells first appeared on News Health.

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Author : News Health

Publish date : 2025-07-23 06:30:00

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