Source link : https://health365.info/researchers-examine-how-air-pollutants-triggers-immune-imbalance-and-lung-harm/
Lengthy-term publicity to PM2.5 and PM10 triggers oxidative strain and turns on the NRF2 pathway, transferring the immune reaction towards TH2 irritation—worsening bronchial asthma and different allergic lung illnesses. Credit score: Professor Changwan Hong from Pusan Nationwide College, Korea
Air pollutants is an international well being fear, with over 90% of the arena’s inhabitants respiring air that exceeds International Well being Group protection requirements. Advantageous and coarse particulate topic are particularly bad, as they may be able to penetrate deep into the lungs and bloodstream. Whilst the hyperlink between air pollutants and respiration illnesses is easily established, how those pollution disrupt immune responses within the lungs has remained unclear.
In a up to date find out about, a staff of researchers led through Professor Changwan Hong from Pusan Nationwide College Faculty of Medication, South Korea, investigated how long-term publicity to particulate topic triggers immune imbalance within the lungs. “Our study reveals how chronic exposure to particulate matter (PM10 and PM2.5) triggers harmful allergic-like (TH2) immune responses in the lungs by activating oxidative stress and the NRF2 pathway,” explains Prof. Hong. This paper used to be revealed inRedox Biology on 1 Might 2025.
The use of a mouse type, the researchers uncovered mice to PM10 and PM2.5 day-to-day for 16 weeks. They then analyzed lung tissue,…
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Publish date : 2025-07-23 19:54:00
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