Source link : https://health365.info/olezarsen-reduces-ranges-of-the-blood-fats-triglycerides-in-sufferers-at-excessive-cardiovascular-possibility-scientific-trial/
Schema for the Essence-TIMI 73b trial. Credit score: American Middle Magazine (2025). DOI: 10.1016/j.ahj.2025.02.022
Olezarsen lowered ranges of triglycerides when put next with placebo in sufferers with reasonable hypertriglyceridemia and increased cardiovascular possibility, in step with a late-breaking trial offered in a Scorching Line consultation on the ESC Congress 2025 and concurrently printed within the American Middle Magazine.
“High levels of triglycerides are an important risk factor for atherosclerotic cardiovascular disease (ASCVD) and yet the effects of current therapies are modest,” defined most important investigator, Dr. Brian Bergmark from the TIMI Find out about Staff, Brigham and Ladies’s Health facility, Harvard Scientific College, Boston, U.S.
He persevered, “Olezarsen targets the mRNA of apolipoprotein C-III, which inhibits triglyceride clearance. Olezarsen has been shown to lower triglyceride levels in small Phase II trials and in patients with very high triglyceride levels. We investigated the efficacy and safety of olezarsen in patients with moderate hypertriglyceridemia at high ASCVD risk in the ESSENCE-TIMI 73b trial.”
The placebo-controlled, double-blind Section III ESSENCE-TIMI 73b trial was once carried out at 160 websites in North The united states and Europe. The trial incorporated grownup sufferers with reasonable hypertriglyceridemia (triglycerides 150–499 mg/dL) and increased cardiovascular…
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Publish date : 2025-09-01 20:32:00
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